Is PDRN Treatment Already Old News?

Your skin matters to you!

However, with all the treatment alternatives it can seem confusing to know which works best for you. Maybe you’re looking for ways to achieve smooth skin, reduce scars, or gain healthy glowing skin or perhaps other benefits associated with new trends at your favorite Chicago MedSpa?

A very valuable feature of PDRN Skin Treatment is that it uses salmon DNA so that your skin can both quickly heal and feel refreshed. Many customers regard it as the “Miracle Healer injection.”

In this blog, we shall explain what PDRN Skin Treatment entails, how it works, and if it can still be regarded as an effective treatment given the times that we now live in. Toward the end of this article, we shall introduce you to other alternatives found at medical spas throughout Chicago.

Is PDRN Skin Treatment Already Outdated? Continue reading to get answers that matter.

Key Takeaways

• The treatment of skin with PDRN uses DNA taken from salmon to treat, moisturize the skin, and to smoothen it. PDRN skin treatment was previously used extensively since 1994 and is commonly found at medical spas located in Chicago.

• The treatment works to smoothen wrinkles, scars, and promote elasticity on the skin through boosting collagen production. For most of these clients, the benefits can only be realized after 3-4 sessions, held at several weeks intervals. There can be benefits lasting up to 36 months.

• More innovative treatments like exosome or growth factor injection therapies can now already be found at most innovative medspas. They would provide benefits faster or more thoroughly but would certainly cost more and require additional research into their sustainable efficacy.

• Experts state that PDRN does not cause irritation to any type of skin, even senescent or sensitive skin. It does however, have limitations. For instance, those with keloid problems or infections should not utilize PDRN treatments. For best results, treatment should be done every 6-12 months.

• By introducing PDRN and Hyaluronic acid into a patient’s body, it boosts the level at which the wound can heal to 67%, from 22%, without any other products or treatments. More importantly, medical practitioners suggest incorporating a mix of technologies – old and new – to find what works well.

What Is PDRN Skin Treatment?

PDRN skin treatment uses DNA fragments which help with the healing and regeneration of skin. PDRN is produced using salmon sperm DNA; this particular DNA helps stimulate skin cells, leading to improved skin health.

Definition and origins of PDRN

PDRN refers to Polydeoxyribonucleotide, extracted from the sperm DNA of salmon. The process involved in deriving PDRN has specific handling to eliminate any immunogenic proteins; hence a reduced concern of allergic reactions.

The composition of PDRN includes deoxyribonucleotides ranging from 50-1,500 KDa with peaks at 132 KDa for most types.

PDRN was first found in 1994 to possess the ability to heal and repair tissues. It was initially used as a treatment for wounds and tissue engineering applications because of its marked anti-inflammatory effects and ability to induce new cell growth.

It is best known under the brand name Rejuran, and can be found at top medical facilities and medical spas. It was because of the inherent advantages to this product that medical practitioners showed interest in using it for dermatology purposes; consequently comes the process of how PDRN can make your skin healthier.

How PDRN works on the skin

The treatment aspect of PDRN entails deep-cell repairs. It acts on the Adenosine A2A receptor. It promotes rapid repairs of damaged cells on the skin surface and enhances the production of fibroblasts, which are major cells responsible for producing collagen.

The more collagen there is, the more elastic and healthier your skin will look.

It also promotes the production of collagen to minimize wrinkles and smoothen fine lines. PDRN has high antioxidant and anti-inflammatory properties; these help protect your clients’ skin against damage and decrease inflammation or redness associated with procedures.

Key Benefits of PDRN Skin Treatment

PDRN skin treatments offer many advantages to your skin. It ensures your skin regeneration and moisturization processes; Furthermore, it prevents wrinkles, providing you with the youthful glow of your skin.

Skin regeneration and moisturization

There is an improvement in the feel of the skin because of the increased cellular activity, due to PDRN increasing the rate of metabolism of cells in the skin. It therefore promotes rapid growth of collagen so that the skin appears full and youthful.

More new cells proliferate to fix areas with damage to fight off symptoms of skin exhaustion.

PDRN treatment is well-suited for dry or dehydrated skin because it aids greatly in hydrating the skin cells effectively. It offers smooth textures to the skin and can last for 6 to 36 months; therefore, this procedure has gained popularity among many medspas today.

Minimizing fine lines and wrinkles

PDRN treatment for the skin reduces fine lines and wrinkles, and mainly targets the areas of the face close to the eyes, lips, and forehead. It has been found that using PDRN reduces effectively the signs of aging, by enhancing collagen production in the skin.

Most patients feel and see the effect produced within only a few days following the initial treatment session. For maximum benefit, up to 4 treatment sessions done over a period of 3 to 4 weeks would be ideal. The PDRN has been found to contain anti-inflammatory agents with capability to easily smoothen out facial wrinkles on the skin.

Removal of scars and tissue repair

Scarring and skin repairs can now be diminished with the help of PDRN skin treatment. PDRN skin treatment promotes re-epithelialization processes and hence enhances rapid repairs of damaged skins.

It is also useful when addressing scars caused by acne or stretch marks. Studies conducted on PDRN show that it enhances wound healing for skin grafts and consequently improves skin strength.

PDRN has anti-inflammatory effects too. It can restore sensitive or damaged skin and therefore promotes a superior aesthetic outcome. Also, it can treat areas like the décolletage and below the eyes effectively.
Its safety advantages ensure lower incidence of side effects among patients and provide improved skin health benefits.

Increased skin elasticity

PDRN promotes elasticity and stimulates collagen production. It works together with the stimulation of fibroblast cells; this is vital when it comes to performing in anti-aging roles. PDRN stimulates the receptor found on skin cells; this promotes elasticity to regain a young and refreshed appearance.

Often, PDRN is regarded as an effective treatment in persons beyond 30 years of age, who experience loss of elasticity. The elasticity achieved with this treatment assists greatly in maintaining elasticity of the skin via fibroblast and keratinocyte cells.

It has remained in high demand at aesthetic medical facilities owing to the skin elasticity it offers; more and more customers request this service.

Application Techniques

PDRN can be applied in a few ways.

Direct injections deliver the treatment straight into the skin.

You can also combine it with micro-needling or lasers after other procedures to boost effects.

 

Curious about how this works?

Keep reading to learn more!

Direct injections

This technique requires injecting minute needles containing PDRN or EPRD directly into your skin. Doing so allows for pinpointing exact areas of concern like your forehead, under your eyes, or around your Nose Lines and ACNE Scars. These procedures should be performed by an aesthetic doctor only.

It takes about 30 minutes to perform this treatment. Pain-numbing topical cream can be used to ensure comfort while performing this treatment. Most patients feel that they experience little to no downtime following the procedure. It would take only a few days to achieve a visible outcome based on how easily your skin can heal and recover.

Post-procedure – micro-needling or lasers

Immediate application of PDRN can be done following either micro-needling or laser treatments. The application of PDRN can increase the healing process and can work effectively when done this way.

When there’s micro-needling done on the skin, micro-injuries occur that lead to a higher production of collagen.

After such a procedure, applying PDRN can provide additional hydration benefits.

It should be noted that it is important to treat the skin with caution after performing micro-needling because sunlight or using strong sun-screen products on the skin can cause adverse reactions to occur. Most treatments require applying skin lotions once the skin has healed.

Side effects triggered by micro-needling treatments include reddening and inflammation; however, these problems go away with time. It is important to monitor carefully any adverse reactions caused when using PDRN products.

Is PDRN Still Effective?

Is PDRN still effective? There seem to be many interested in learning if PDRN works with all these innovative technologies now available for taking care of your skin. While it’s clear that PDRN works well, it could probably serve you well to have some alternative options…

Comparison with newer skin treatments

PDRN skin treatments have proven their efficacy and longevity; however, there exist more modern technologies for skin treatments now available with regard to important criteria set forth by those desiring cutting-edge MedSpa skin treatments in the table below:

 

Treatment	How It Works	Key Benefits	Clinical Use	Unique Advantages	Limitations
PDRN (Polydeoxyribonucleotide)	Stimulates cell proliferation and anti-inflammatory responses. Regenerates skin by promoting tissue repair.	Improves hydration, boosts skin elasticity, reduces scars, and smooths wrinkles. Offers regenerative support beyond volume filling.	Over 20 years. Expanding in both medical and cosmetic dermatology. Used in fillers and combination therapies.	Regeneration-focused. Efficacy proven in long-term clinical studies. Complements other skin rejuvenation methods.	Results depend on individual skin type. Not as immediate as some fillers or lasers. Needs multiple sessions.
Exosome-Based Therapies	Delivers cellular messengers to boost skin repair and collagen production. Uses nano-particles from stem cells.	Targets pigmentation, fine lines, and inflammation. May accelerate healing after procedures.	Emerging since 2019. Rapid adoption in advanced medspas. Used post-laser and micro-needling.	Targets skin at molecular level. Minimal downtime. Growing interest for difficult conditions.	Long-term effects still being studied. Cost higher than traditional options. Limited by regulatory approval in some regions.
Growth Factor Treatments	Delivers bio-identical growth factors that encourage cell turnover and tissue repair.	Reduces aging signs, enhances skin tone, and speeds up recovery from injury or laser.	Increasing use in aesthetic clinics since 2017. Often applied with micro-needling.	Quick results. Often paired with other therapies. Good for post-procedure recovery.	Shorter duration of effect. May not address deeper tissue aging. Some patients may not respond.
Hyaluronic Acid-Based Fillers	Restores volume by attracting moisture. Provides structural support beneath the skin.	Immediate plumping effect. Smooths fine lines. Hydrates skin surface.	Standard in medspas since early 2000s. Wide FDA approval.	Fast results. Reversible. High safety profile.	No regenerative benefits. Lasts 6-12 months. Focuses on filling rather than healing.

Breakthroughs in regenerative skin therapies

The technologies for regenerative skin therapies are moving at a rapid pace. Exosome and PDRN therapies could well prove to be promising alternatives for the future. These technologies can help increase your level of well-being; indeed, your skin looks healthier and more attractive. PDRN has been proven to stimulate Adenosine A2a receptors; this helps with your skin regeneration processes. It can heal your skin and make you look younger.

More recent research now shows how important immune responses with Toll-like receptors are; These responses can enhance regenerative activity on the skin.

The combination of using PDRN with other medications would probably amplify these advantages even more. It has promising prospects for taking care of your skin at medical spas.

Limitations of PDRN Skin Treatment

PDRN skin treatment may not suit everyone, as individual skin types and conditions can affect its results. Curious about what that means for you? Keep reading!

Suitability for different skin types

PDRN dermal treatment can easily be applied to every skin type. It works well to reduce inflammation and acts as an antioxidant without any fear of hyper-pigmentation. Typically it can be applied to patients ranging between the ages of 25-60.

It is well-suited for sensitive skin and even rosacea or pimple scars.

Not every patient is recommended to undergo PDRN treatment. Individuals with a tendency to develop keloid or hypertrophic scars should not opt for PDRN treatment. An active infection or eczema causes a risk for PDRN use, and treatment should be delayed. Taking isotretinoin or having undergone any procedure on your skin recently will limit you from receiving PDRN treatment.

Dependency on individual skin conditions

Skin treatment with PDRN can differ when it comes to efficacy; It depends largely on your individual skin type, condition, and other factors like cellular turnover.

People with concerns about their skin like acne scars or cuts can experience great benefits, with maintenance therapy every 6 to 12 months.

Keep in mind, It’s not a solution for every dermal concern.

There could be clients with these kinds of expectations curious to know if treatment could wipe off all scars. It depends on physical differences among clients.

Every case requires individual treatment because only this can ensure optimal outcomes of PDRN therapy.

Alternatives to PDRN Skin Treatment

Alternatives to PDRN skin treatments frequently consist of other treatment products, with options such as exosome or growth factors; Both of which would offer equal benefits for skin maintenance and care. Having such a variety of alternatives allows you to find what works best for you.

Exosome-based therapies

Exosome Therapy works with vesicles between 30 and 150 nanometers. Exosomes contain RNAs, proteins, lipids, growth factors, and cytokines. These molecules originate from human cells and plant cells. In this treatment, multiple skin signaling pathways are involved.

Exosomes induce more collagen, elastin, and hyaluronic acid than PDRN. Exosomes generate a low level of immune rejection. Patients can feel a substantial difference in their skin topography with exosome treatment.

Exosomes show strong antioxidant activity and assist with immune system modulation to provide adequate skin health.

Growth factor treatments

Regarding regenerative medicine, growth factors treatment can successfully treat skin problems. These factors contain anti-inflammatory/antioxidant factors.

These factors assist with decreasing inflammation and preventing free radicals’ action on the skin. A treatment regime over several months will promote regenerating dermal tissues and can therefore be said to provide optimal alternatives for wrinkle and dry skin treatment.

Alternatively they have been used for baldness (alopecia) and psoriasis treatment, apart from the usual aesthetic purposes. Growth factors found in certain dermal fillers assist with regenerating and tightening the skin, which has been found to work well in combination with PDRN treatment.

Now, let’s discuss how these treatments can be applied using PDRN treatment.

Combination therapies with hyaluronic acid

Combination therapies with hyaluronic acid improve skin healing.

The use of hyaluronic acid in a combination of therapies promote accelerated healing of the skin. It has been observed that 67% of patients experience complete healing of the skin when treated simultaneously with PDRN and hyaluronic acid.

This marks a significant improvement over the 22% success rate among patients treated with hyaluronic acid alone. Hyaluronic acid moisturizes well, yet lacks regenerative properties associated with PDRN.

These treatments together would therefore work best among patients with complex skin concerns.

There are several studies on-going, to identify ways and means whereby these products would benefit patients more in terms of safety and efficacy at medical spas worldwide.

Expert Opinions on PDRN Relevance

Experts share mixed views on PDRN’s role in skin care. Some dermatologists see it as a valuable option, while others point to newer treatments as more effective choices…

Time will tell if PDRN remains relevant.

Dermatologists’ perspectives

Dermatologists consider PDRN effective in treating wrinkles, dryness, and hyperpigmentation.

The procedure has little downtime and high satisfaction rates among patients. Dermatologists find PDRN safe and effective for most patients, including those with sensitive skin.

Many physicians recommend 3-6 visits spaced 4 weeks apart. This would seem like the most effective protocol.

The use of PDRN stands out as relatively risk-free and provides rejuvenating and restorative advantages. Going ahead in the future, the need arises to consider other alternative solutions in addition to PDRN skin therapy.

Trends in aesthetic medicine

PDRN is now readily accepted in the skin renewal industry. Many medical spas are now incorporating PDRN in their treatment options. This can be combined with other products like Hyaluronic Acid and Growth Factors.

This mix represents a new trend because it enhances outcomes for clients.

The trend towards treatments requiring fewer downtime days persists. Clients are now opting for treatments conducted once per month in attempts to maintain their skin care in the most convenient way possible.

Others now include exosome treatments in the list of alternatives compared to PDRN.

All of this illustrates how quickly the aesthetic medicine industry is changing. Going forward, it would be vital to consider how effective PDRN remains in comparison to other more current treatments.

Conclusion

PDRN skin treatment has many benefits. It helps heal wounds and hydrates the skin. Many people see results within a few days. New treatments are emerging, but PDRN still plays a role in skincare.

Some might find alternatives more suitable for their needs.

 

What do you think?

Would you consider trying PDRN or exploring other options?

It’s important to stay informed and choose what works best for your skin care journey.

Taking care of your skin can significantly improve your confidence and well-being.